| Frequency | One procedure — done | Every 12 weeks | Monthly or quarterly injections | Repeated in-clinic injections | As needed — taken at attack onset |
| Ongoing cost | One-time procedure cost | ~$3,500–$5,000/year — ongoing for life | ~$6,900/year (Aimovig) — ongoing for life | Varies — per-treatment office visits | Monthly pharmacy cost — ongoing |
| Predictive test | Yes — lidocaine screen predicts response before you commit | No — you try it and wait to see | No — you try it and wait to see | No — you try it and wait to see | No — you take one and see if it helps |
| Drug-free | Yes — no ongoing medications after the procedure | No — injectable medication every 12 weeks | No — ongoing injections or daily pills | Local anesthetic injections — no daily preventive pills | No — pills taken at each attack |